Technology
MicroOrganoTech provides a scalable next-generation micro-physiological system (MPS) platform for disease modeling and drug testing.Our revolving organ-on-chip (rOoC) technology is based on a patented fluidic layout combined with a 3D tilting apparatus that produces a directed gravity-driven flow without the need for pumps and tubes.
The rOoC platform enables the functional culture of multiple 3D organ models, endothelial cells, and the integration of circulating cells such as immune cells or particles. All these elements can be coupled together in different combinations in one microfluidic device, allowing the development of complex tissue and organ representations and advanced disease models.
Our pump-less approach ensures high scalability and user-friendliness for drug discovery and drug testing in both academic and industrial R&D laboratories.
Microfluidics
Pumb-less resolving organ-on-chip (rOoC) platform that addresses central shortfalls of the OoC field in a robust and scalable configuration.
- Supports multiple 3D organ models, blood vessels and circulating cell (e.g. immune cells).
- Generates directional flow without pumps.
- Plate and single chip format.Design optimized for different organ models.
- Copatible with automated pippeting robots.
- No pumps needed.High scalability.
- User-friendly.
- Live-cell imaging.
- PDMS-free (no drug absorption).
Single-use rOoC chips are avaliable in different layouts, optimized for different organ models and biological questions. rOoC chips are shipped in a sterile, ready-to-use bag as single chips or as arrays of several rOoCs in the well plate format.
We currently offer the following rOoC layouts:
| Single-Loop | Loop-in-Loop | Infinity-Loop |
|---|---|---|
| Combination of two large organoid/cell chambers in one perfusion loop. | Combination of two smaller organoid chambers placed between two independent perfusion loops. | Incorporates a membrane between two separate perfusion loops. Each loop includes one organoid chamber. |
| Suitable for demanding or big organoids, vascularization and immune infiltration. | Suitable for applications that require gradient formation, for studying immune infiltration and vascularization, and organ integration. | This unique layout adds an endothelial/epithelial barrier between both loops, thus adding the option to study drug or immune cell transport/adsorption. |
We also provide a customized tilting system to run the devices. Please contact us for information and pricing.
Publication in "Lab on a Chip": Pump-less, recirculating organ-on-a-chip (rOoC) platform (pdf)Team
MicroOrganoTech is an innovation project from Oslo, Norway that aims to spin out as a startup company from the Hybrid Technology Hub – Centre of Excellence (HTH-CoE) at the University of Oslo.
The technology has been developed by Mathias Busek (Ph.D.), who has more than 10 years of experience in the OoC field and pioneered an OoC platform with integrated pneumatic micro-pumps at TU Berlin (now used for drug screening by TissUse GmbH). He is leading the platform and technological developments at MicroOrganoTech.
Biological use-cases development and incorporation of advanced 3D culture models into the platform is led by Alexandra Aizenshtadt (Ph.D.), who has both entrepreneur and academic experience (more than 10 years of experience in cell biology and disease modeling, and worked in interdisciplinary commercial and academic teams).
The team is complemented by Prof. Stefan Krauss, director of the HTH-CoE and an international expert in developmental biology and drug development with a broad experience in academic/industrial collaborations.
Petter Angell Olsen (Ph.D.) brings expertise in molecular cell biology, gene-editing technologies, and mechanobiology, combined with extensive operational and administrative leadership experience from the HTH-CoE, where he oversees research infrastructure and organizational management.
Peter Loskill (Ph.D.) is a bioengineer and expert in Organ-on-a-Chip systems and alternatives to animal testing. He leads the Department of Microphysiological Systems at the University of Tübingen, the 3R Center for in vitro models and alternatives to animal testing, and the Organ-on-Chip group at NMI.
Dr. Mathias Busek
Dr. Aleksandra Aizenshtat
Prof. Stefan Krauss
Dr. Petter Angell Olsen
Prof. Peter Loskill
Contact
If you are interested in a collaboration or want more information about our products, please contact us.
MicroOrganoTech
E-Mail: contact@microorganotech.com